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Evidence-Based Total Intravenous Anesthesia & TCI Precision

Advancing clinical neuroprotection, processed EEG depth monitoring, and target-controlled infusion through peer-reviewed evidence.

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-54% POCD Risk
99.4% EEG Stability
3.2x Faster Recovery
TCI & EEG Telemetry Matrix
Schnider Model
EEG CHANNEL 1 — BIS / ENTROPY DEPTH BIS: 46 TCI PROPOFOL EFFECT-SITE CONCENTRATION (Ce) Ce Target: 3.5 mcg/mL Cp: 3.48 mcg/mL Flow: 42.5 mL/h STATUS: TARGET STABLE
Peer-Reviewed Data

Clinical Evidence & Outcome Impact Dashboard

Key empirical metrics demonstrating significant risk reduction in cognitive impairment, delirium, and PACU recovery times under total intravenous anesthesia.

Level-1 Meta-Analysis PMID 35874550
54% Reduction
OR 0.46 (95% CI: 0.26–0.81, p=0.01)

POCD Risk Reduction

Reduction in Postoperative Cognitive Dysfunction (POCD) risk within the first 30 days post-surgery with TIVA versus volatile inhalational anesthesia based on Level-1 meta-analysis of 3,390 patients across 10 trials.

Negrini D et al. Neuropsychiatr Dis Treat. 2022.
View PubMed Evidence
Randomized Trial (RCT) PMID 38987101
8.8% vs 34.2%
p = 0.027, OR = 1.72 (Elderly >65y: 14.2% vs 63.6%)

Postoperative Delirium in CABG

ICU delirium incidence in adult patients undergoing CABG with CPB, falling from 34.2% with inhaled sevoflurane to 8.8% with propofol TIVA in a prospective randomized trial.

Varsha AV et al. J Cardiothorac Vasc Anesth. 2024.
View PubMed Evidence
Randomized Trial (RCT) PMID 36239660
16.5–38.5 min
p = 0.004 overall, p = 0.024 in palate surgery

PACU Recovery Time Saved

Accelerated Phase I PACU discharge time in obstructive sleep apnea (OSA) patients undergoing upper airway surgery under propofol TIVA versus volatile anesthesia.

Estephan LE et al. Laryngoscope. 2023.
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